Monogenic forms of systemic lupus erythematosus: new insights into SLE pathogenesis

PReS-FINAL-2173: Protein kinase C delta deficiency is a new cause of monogenic SLE

Introduction Systemic lupus erythematosus (SLE) is a prototype autoimmune disease. Infectious triggers, genetic background, immunological abnormalities and environmental factors are all supposed to interact in disease development. Rare causes of monogenic SLE have been described, (e.g. complement deficiencies, interferonopathies and FasL deficiency) providing unique insights into fundamental me...

Effects of Major Epigenetic Factors on Systemic Lupus Erythematosus

The pathogenesis of systemic lupus erythematosus (SLE) is influenced by both genetic factors and epigenetic modifications; the latter is a result of exposure to various environmental factors. Epigenetic modifications affect gene expression and alter cellular functions without modifying the genomic sequences. CpG-DNA methylation, histone modifications, and miRNAs are the main epigenetic factors ...

A review on the latest clinical and laboratory criteria for clinical diagnosis of Systemic Lupus Erythematosus

Systemic Lupus Erythematosus (SLE) is a complex autoimmune disease with various organs involvement which early diagnosis of disease is critical for successful treatment. The subjects with the possibility of SLE who visit by physician, their full medical history and specific immunological tests should investigate precisely in order to subsequently asses their hematological and renal parameters t...

NEW INSIGHTS INTO THE PATHOGENESIS OF SYSTEMIC LUPUS ERYTHEMATOSUS (SLE): the role of apoptosis

IL-17 is Aberrantly Overexpressed Among Under-treatment Systemic Lupus Erythematosus Patients

Background & Objective: Systemic lupus erythematosus (SLE) is an autoimmune disease with chronic inflammatory immune response. Current therapies mostly rely on glucocorticoids which are accompanied by side-effects and mostly fail to achieve a favorable remission. Th17 subpopulation of T cells is increased in exacerbated SLE as IL-17 cytokine is overexpressed. ...